The Effects Of Air Pollution On Cardiovascular Disease

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The Effects of Air Pollution on Cardiovascular Disease

One could use at this point the fact that people cardio-clear-7 on statins (cholesterol lowering drugs) have lower risks for heart disease. The thing with these studies is that the cardioprotective role of statins seems to be completely irrelevant with the cholesterol or LDL level in the blood serum. Specifically in the studies testing the statins the cardioprotective effect of these drugs was present equally to patients with low or high cholesterol levels. This leads us the suspicion that this effect might be due to a different reason and not cholesterol levels as it has been falsely promoted so much. Indeed a look at the biochemical action of statins reveals that these drugs block the synthesis of a molecule called mevalonate which a precursor molecule for the subsequent synthesis of cholesterol. The details of the biochemical pathways are of no importance at this point but the only extra piece of information we need is that mevalonate is a precursor molecule for many more things, not just cholesterol. Further experiments reveal that statins affect the ability of platelets to stick to each other by preventing them to produce a substance that triggers just that. This means that the mechanism of blood clogging is blocked thus leading to substantially lower number of infractions i.e. heart attacks and strokes. Also statins were found to lower the activity of smooth muscle cells. One of the first steps in the advancement of atherosclerosis is the migration of smooth muscle cells at the points of arterial damage. By blocking these two mechanisms, statins' cardioprotective effect can be explained. Please note that both mechanisms are cholesterol independent confirming the experimental data that statins have such an effect equally to people with low or high blood cholesterol.

Statins are not to be taken lightly though. They have severe side effects that do not compensate even for the small cardioprotective role they have. The list is quite long really but the most basics include impaired cognitive functions, memory loss, kidney and liver failure and severe muscle damage. Also statins have been correlated with increased risk of cancer and 50 % of the pregnant women who took statins during the first months of their pregnancy gave birth to children with malformations worse than the cases of thalidomide.

 

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